SLC2A9

Chr 4p16.1

solute carrier family 2 member 9

Aliases:: Glut9, GLUTX, URATv1
MANE:: ENST00000264784.8

OMIM: 606142 ↗NCBI: 56606 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

SLC2A9 · Q9NRM0

v62025-08-01

Predicted Aligned Error matrix for SLC2A9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.6/ 100

Confident

540 residues

Confidence breakdown

Very high(≥ 90)53%
Confident(70–90)33%
Low(50–70)2%
Very low(< 50)12%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Nephrocalcinosis or nephrolithiasis
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Renal tubulopathies
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Acute rhabdomyolysis
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Rhabdomyolysis and metabolic muscle disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

hypouricemia, renal, 2
0.78
gout
0.60
hyperuricemia
0.56
alcohol drinking
0.46
hereditary renal hypouricemia
0.39
physical activity
0.38
renal tubular transport disease
0.37
arthropathy
0.36
chronic kidney disease
0.35
bladder calculus
0.35

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Solute carrier family 2, facilitated glucose transporter member 9

High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:18327257, PubMed:18701466, PubMed:22647630, PubMed:28083649, PubMed:36749388). May have a residual high-affinity, low-capacity glucose and fructose transporter activity (PubMed:18327257, PubMed:18701466, PubMed:18842065). Transports urate at rates 45- to 60-fold faster than glucose (PubMed:18842065). Does not transport galactose (PubMed:28083649). May mediate small uptake of adenine but not of other nucleobases (PubMed:22647630)

Curated MONDO disease pages that list SLC2A9 among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with SLC2A9