AlphaFold predicted structure
SLC30A10 · Q6XR72
Mean pLDDT
67.5/ 100
Low
485 residues
Confidence breakdown
- Very high(≥ 90)26%
- Confident(70–90)32%
- Low(50–70)9%
- Very low(< 50)33%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
SLC30A10
Chr 1q41solute carrier family 30 member 10
- Aliases:
- DKFZp547M236, ZnT-10, ZRC1, ZNT8, ZNT10
- MANE:
- ENST00000366926.4
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Adult onset dystonia, chorea or related movement disorder
BIALLELIC, autosomal or pseudoautosomalChildhood onset dystonia, chorea or related movement disorder
BIALLELIC, autosomal or pseudoautosomalEarly onset dystonia
BIALLELIC, autosomal or pseudoautosomalHereditary Erythrocytosis
BIALLELIC, autosomal or pseudoautosomalLikely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalParkinson Disease and Complex Parkinsonism
BIALLELIC, autosomal or pseudoautosomalStructural basal ganglia disorders
BIALLELIC, autosomal or pseudoautosomalUndiagnosed metabolic disorders
BIALLELIC, autosomal or pseudoautosomal
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Disease associations (Open Targets)
Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome
0.79cirrhosis - dystonia - polycythemia - hypermanganesemia syndrome
0.74nephrolithiasis
0.44bladder calculus
0.37extrahepatic bile duct carcinoma
0.34ureterolithiasis
0.29urolithiasis
0.29diverticular disease
0.25hereditary disease
0.19androgenetic alopecia
0.18
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Calcium/manganese antiporter SLC30A10
Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange (PubMed:30755481). Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis (PubMed:22341972, PubMed:25319704, PubMed:26728129, PubMed:27226609, PubMed:27307044). Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (PubMed:22427991, PubMed:26728129)