SLC30A7

Chr 1p21.2

solute carrier family 30 member 7

Aliases:: ZnTL2, ZNT7
MANE:: ENST00000357650.9

OMIM: 611149 ↗NCBI: 148867 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC30A7 · Q8NEW0

v62025-08-01

Predicted Aligned Error matrix for SLC30A7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

75.6/ 100

Confident

376 residues

Confidence breakdown

Very high(≥ 90)34%
Confident(70–90)41%
Low(50–70)5%
Very low(< 50)21%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Ziegler-Huang syndrome
0.50
Joubert syndrome 1
0.33
Decreased testicular size
0.27
severe early-onset pulmonary alveolar proteinosis due to MARS deficiency
0.27
Testicular atrophy
0.27
multiple sclerosis
0.26
Fuchs endothelial corneal dystrophy
0.10
posterior polymorphous corneal dystrophy
0.09
X-linked corneal dermoid
0.09
congenital hereditary endothelial dystrophy of cornea
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc transporter 7

Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed:15525635, PubMed:15994300). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (PubMed:15525635, PubMed:15994300)