SLC37A3

Chr 7q34

solute carrier family 37 member 3

Aliases:: DKFZp761N0624, SPX3
MANE:: ENST00000326232.14

OMIM: 619137 ↗NCBI: 84255 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC37A3 · Q8NCC5

v62025-08-01

Predicted Aligned Error matrix for SLC37A3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.4/ 100

Confident

494 residues

Confidence breakdown

Very high(≥ 90)59%
Confident(70–90)24%
Low(50–70)7%
Very low(< 50)10%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Retinal disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

retinitis pigmentosa
0.37
brain compression
0.28
edema
0.28
Vertigo
0.06
Meniere disease
0.06
crush injury
0.05
idiopathic pulmonary fibrosis
0.05
androgenetic alopecia
0.04
breast carcinoma
0.04
type 2 diabetes mellitus
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Sugar phosphate exchanger 3

Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity (PubMed:21949678). In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899)