SLC39A13

Chr 11p11.2

solute carrier family 39 member 13

Aliases:: FLJ25785, LZT-Hs9, ZIP13, ZIP-13
MANE:: ENST00000362021.9

OMIM: 608735 ↗NCBI: 91252 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC39A13 · Q96H72

v62025-08-01

Predicted Aligned Error matrix for SLC39A13 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

75.3/ 100

Confident

371 residues

Confidence breakdown

Very high(≥ 90)38%
Confident(70–90)28%
Low(50–70)15%
Very low(< 50)19%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Ehlers Danlos syndrome with a likely monogenic cause
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Thoracic aortic aneurysm or dissection
BIALLELIC, autosomal or pseudoautosomal
Thoracic aortic aneurysm or dissection (GMS)
BIALLELIC, autosomal or pseudoautosomal
Osteogenesis imperfecta

Disease associations (Open Targets)

Ehlers-Danlos syndrome, spondylocheirodysplastic type
0.73
spondylodysplastic Ehlers-Danlos syndrome
0.38
spondyloepimetaphyseal dysplasia-abnormal dentition syndrome
0.37
Spondyloepimetaphyseal dysplasia - abnormal dentition
0.37
prostate carcinoma
0.29
hypertensive disorder
0.22
stroke disorder
0.22
Alzheimer disease
0.22
Ehlers-Danlos syndrome
0.20
hereditary disease
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc transporter ZIP13

Functions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed:21917916, PubMed:23213233). May regulate beige adipocyte differentiation (By similarity)