SLC39A7

Chr 6p21.32

solute carrier family 39 member 7

Aliases:: H2-KE4, D6S2244E, KE4, RING5, ZIP7
MANE:: ENST00000374677.8

OMIM: 601416 ↗NCBI: 7922 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC39A7 · Q92504

v62025-08-01

Predicted Aligned Error matrix for SLC39A7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

66.2/ 100

Low

469 residues

Confidence breakdown

Very high(≥ 90)21%
Confident(70–90)27%
Low(50–70)13%
Very low(< 50)39%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Epidermolysis bullosa and congenital skin fragility

Disease associations (Open Targets)

agammaglobulinemia 9, autosomal recessive
0.59
agammaglobulinemia
0.51
B cell deficiency
0.46
neurodegenerative disease
0.45
Alzheimer disease
0.25
lysosomal storage disease
0.25
multiple sclerosis
0.25
Parkinson disease
0.25
breast cancer
0.09
type 2 diabetes mellitus
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc transporter SLC39A7

Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:14525538, PubMed:15705588, PubMed:28205653, PubMed:29980658). Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation (PubMed:22317921, PubMed:28205653, PubMed:29980658). Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function (By similarity). Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts (PubMed:29980658, PubMed:30237509). Mediates Zn(2+)-induced ferroptosis (PubMed:33608508)