SLC4A3

Chr 2q35

solute carrier family 4 member 3

Aliases:: AE3, SLC2C
MANE:: ENST00000358055.8

OMIM: 106195 ↗NCBI: 6508 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

SLC4A3 · P48751

v62025-08-01

Predicted Aligned Error matrix for SLC4A3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

66.7/ 100

Low

1,232 residues

Confidence breakdown

Very high(≥ 90)28%
Confident(70–90)30%
Low(50–70)8%
Very low(< 50)34%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Short QT syndrome
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Familial short QT syndrome
0.44
short QT syndrome 7
0.43
short QT syndrome
0.23
ulcerative colitis
0.22
hereditary disease
0.20
ventricular fibrillation
0.19
cardiac arrest
0.18
Abnormality of the cardiovascular system
0.16
Abnormality of the skeletal system
0.15
cholelithiasis
0.15

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Anion exchange protein 3

Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:29167417, PubMed:7923606). May be involved in the regulation of intracellular pH, and the modulation of cardiac action potential (PubMed:29167417)