SLC5A5

Chr 19p13.11

solute carrier family 5 member 5

Aliases:: NIS
MANE:: ENST00000222248.4

OMIM: 601843 ↗NCBI: 6528 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

SLC5A5 · Q92911

v62025-08-01

Predicted Aligned Error matrix for SLC5A5 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.3/ 100

Confident

643 residues

Confidence breakdown

Very high(≥ 90)59%
Confident(70–90)21%
Low(50–70)4%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Congenital hypothyroidism
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Inherited non-medullary thyroid cancer
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

familial thyroid dyshormonogenesis
0.78
thyroid dyshormonogenesis 1
0.72
congenital hypothyroidism
0.46
hereditary disease
0.19
follicular thyroid adenoma
0.19
Primary amenorrhea
0.12
neoplasm
0.12
breast cancer
0.11
breast carcinoma
0.11
thyroid gland carcinoma
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Sodium/iodide cotransporter

Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:20797386, PubMed:31310151, PubMed:32084174, PubMed:8806637, PubMed:9329364). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351)