SLC6A9

Chr 1p34.1

solute carrier family 6 member 9

Aliases:: GLYT1, GlyT-1
MANE:: ENST00000372310.8

OMIM: 601019 ↗NCBI: 6536 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC6A9 · P48067

v62025-08-01

Predicted Aligned Error matrix for SLC6A9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.1/ 100

Confident

706 residues

Confidence breakdown

Very high(≥ 90)62%
Confident(70–90)15%
Low(50–70)5%
Very low(< 50)18%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Arthrogryposis
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

atypical glycine encephalopathy
0.77
neurodegenerative disease
0.42
schizophrenia
0.41
arthrogryposis
0.37
infantile glycine encephalopathy
0.37
erythropoietic protoporphyria
0.32
hereditary disease
0.19
attention deficit-hyperactivity disorder
0.13
Hematemesis
0.13
metabolic disease
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Sodium- and chloride-dependent glycine transporter 1

Sodium- and chloride-dependent glycine transporter (PubMed:37962965, PubMed:8183239). Essential for regulating glycine concentrations at inhibitory glycinergic synapses