SLC7A7

Chr 14q11.2

solute carrier family 7 member 7

Aliases:: y+LAT-1, Y+LAT1
MANE:: ENST00000674313.1

OMIM: 603593 ↗NCBI: 9056 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

SLC7A7 · Q9UM01

v62025-08-01

Predicted Aligned Error matrix for SLC7A7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.8/ 100

Confident

511 residues

Confidence breakdown

Very high(≥ 90)57%
Confident(70–90)29%
Low(50–70)4%
Very low(< 50)10%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Childhood interstitial lung disease
BIALLELIC, autosomal or pseudoautosomal
COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Familial pulmonary fibrosis
BIALLELIC, autosomal or pseudoautosomal
Hyperammonaemia
BIALLELIC, autosomal or pseudoautosomal
Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Undiagnosed metabolic disorders
BIALLELIC, autosomal or pseudoautosomal
Childhood onset dystonia, chorea or related movement disorder

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Disease associations (Open Targets)

lysinuric protein intolerance
0.85
autoinflammatory syndrome
0.41
Sensorineural hearing impairment
0.37
type 2 diabetes mellitus
0.29
hereditary disease
0.19
amino acid metabolism disease
0.19
cancer
0.09
non-small cell lung carcinoma
0.08
colorectal carcinoma
0.07
benign neoplasm of pituitary gland
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Y+L amino acid transporter 1

Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:10080182, PubMed:10655553, PubMed:14603368, PubMed:15756301, PubMed:15776427, PubMed:17329401, PubMed:9829974, PubMed:9878049). Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (PubMed:15280038, PubMed:31705628). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity)