SLF2

Chr 10q24.31

SMC5/6 complex localization factor 2

Aliases:: FLJ10512, FLJ25012, hNSE6
MANE:: ENST00000238961.9

OMIM: 610348 ↗NCBI: 55719 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLF2 · Q8IX21

v62025-08-01

Predicted Aligned Error matrix for SLF2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

55.0/ 100

Low

1,173 residues

Confidence breakdown

Very high(≥ 90)9%
Confident(70–90)28%
Low(50–70)8%
Very low(< 50)56%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Monogenic short stature
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Atelis syndrome 1
0.71
Abnormality of the skeletal system
0.42
anaphylaxis
0.24
hereditary disease
0.19
obesity disorder
0.18
vascular disorder
0.18
esophageal squamous cell carcinoma
0.07
diffuse large B-cell lymphoma
0.07
sleep apnea syndrome
0.07
lymphoma
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

SMC5-SMC6 complex localization factor protein 2

Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674)