AlphaFold predicted structure
SLITRK6 · Q9H5Y7
Mean pLDDT
67.6/ 100
Low
841 residues
Confidence breakdown
- Very high(≥ 90)25%
- Confident(70–90)33%
- Low(50–70)7%
- Very low(< 50)35%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
SLITRK6
Chr 13q31.1SLIT and NTRK like family member 6
- Aliases:
- FLJ22774
- MANE:
- ENST00000647374.2
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
high myopia-sensorineural deafness syndrome
0.69hearing loss, autosomal recessive
0.39Global developmental delay
0.34Hypercholesterolemia
0.31oligodendroglioma
0.30spinal stenosis
0.28schizophrenia
0.28urolithiasis
0.26celiac disease
0.25adolescent idiopathic scoliosis
0.25
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
SLIT and NTRK-like protein 6
Regulator of neurite outgrowth required for normal hearing and vision