SNAP25

Chr 20p12.2

synaptosome associated protein 25

Aliases:: SNAP-25, RIC-4, RIC4, SEC9, bA416N4.2
MANE:: ENST00000254976.7

OMIM: 600322 ↗NCBI: 6616 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

SNAP25 · P60880

v62025-08-01

Predicted Aligned Error matrix for SNAP25 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.4/ 100

Confident

206 residues

Confidence breakdown

Very high(≥ 90)58%
Confident(70–90)22%
Low(50–70)9%
Very low(< 50)12%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Ataxia and cerebellar anomalies - narrow panel
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Early onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Congenital myaesthenic syndrome
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Congenital myasthenic syndromes
0.69
benign essential blepharospasm
0.53
Spasticity
0.53
skin aging
0.53
overactive bladder
0.52
migraine disorder
0.52
botulism
0.51
urgency urinary incontinence
0.50
developmental and epileptic encephalopathy
0.50
cervical cancer
0.46

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Synaptosomal-associated protein 25

t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells