SNX10

Chr 7p15.2

sorting nexin 10

MANE:: ENST00000338523.9

OMIM: 614780 ↗NCBI: 29887 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

SNX10 · Q9Y5X0

v62025-08-01

Predicted Aligned Error matrix for SNX10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.3/ 100

Confident

201 residues

Confidence breakdown

Very high(≥ 90)66%
Confident(70–90)9%
Low(50–70)20%
Very low(< 50)5%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Hydrocephalus
BIALLELIC, autosomal or pseudoautosomal
Osteopetrosis
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Autosomal recessive malignant osteopetrosis
0.78
metabolic syndrome
0.39
hypertensive disorder
0.37
response to xenobiotic stimulus
0.35
smoking behavior
0.32
osteopetrosis
0.28
cardiovascular disorder
0.27
male reproductive organ cancer
0.26
Abnormality of the skeletal system
0.20
nephrotic syndrome
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Sorting nexin-10

Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption