SOCS1

Chr 16p13.13

suppressor of cytokine signaling 1

Aliases:: SOCS-1, SSI-1, JAB, TIP3, Cish1
MANE:: ENST00000332029.4

OMIM: 603597 ↗NCBI: 8651 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SOCS1 · O15524

v62025-08-01

Predicted Aligned Error matrix for SOCS1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.1/ 100

Confident

211 residues

Confidence breakdown

Very high(≥ 90)66%
Confident(70–90)9%
Low(50–70)15%
Very low(< 50)10%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
COVID-19 research
Unknown

Disease associations (Open Targets)

autoinflammatory syndrome with immunodeficiency
0.71
diffuse large B-cell lymphoma
0.53
psoriasis
0.45
common variable immunodeficiency
0.39
lymphoma
0.38
psoriasis vulgaris
0.38
Hodgkins lymphoma
0.37
lymphoid neoplasm
0.37
non-functioning pituitary adenoma
0.37
neoplasm of mature B-cells
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Suppressor of cytokine signaling 1

Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:32499645, PubMed:33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480)