SPARC

Chr 5q33.1

secreted protein acidic and cysteine rich

Aliases:: ONT, BM-40
MANE:: ENST00000231061.9

OMIM: 182120 ↗NCBI: 6678 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SPARC · P09486

v62025-08-01

Predicted Aligned Error matrix for SPARC — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.3/ 100

Confident

303 residues

Confidence breakdown

Very high(≥ 90)77%
Confident(70–90)1%
Low(50–70)4%
Very low(< 50)19%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Osteogenesis imperfecta
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

osteogenesis imperfecta
0.71
neurodegenerative disease
0.44
hereditary disease
0.41
osteogenesis imperfecta type 4
0.38
Abnormality of the skeletal system
0.35
preeclampsia
0.24
cervical carcinoma
0.12
neoplasm
0.12
gastric cancer
0.12
colorectal carcinoma
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

SPARC

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity