SPATC1L

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

• Monogenic hearing loss

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

• neurodegenerative disease

  0.30

• chronic laryngitis

  0.26

• placental abruption

  0.26

• deafness

  0.18

• spermatogenic failure

  0.10

• spermatogenic failure 20

  0.07

• spermatogenic failure 42

  0.07

• spermatogenic failure 82

  0.07

• spermatogenic failure 72

  0.06

• spermatogenic failure 49

  0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.