SPIN4

Chr Xq11.1

spindlin family member 4

Aliases:: FLJ44984, TDRD28
MANE:: ENST00000374884.3

OMIM: 301113 ↗NCBI: 139886 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SPIN4 · Q56A73

v62025-08-01

Predicted Aligned Error matrix for SPIN4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.9/ 100

Confident

249 residues

Confidence breakdown

Very high(≥ 90)63%
Confident(70–90)14%
Low(50–70)8%
Very low(< 50)15%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Fetal anomalies
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

Disease associations (Open Targets)

Lui-Jee-Baron syndrome
0.42
rheumatoid arthritis
0.30
type 2 diabetes mellitus
0.26
diabetes mellitus
0.21
myocardial ischemia
0.17
hypertensive disorder
0.15
response to xenobiotic stimulus
0.15
heart disorder
0.15
depressive disorder
0.15
obesity due to melanocortin 4 receptor deficiency
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Spindlin-4

Binds to acetylated and methylated histones, including H3K4me3 and H4K20me3, probably acting as a histone reader that recognizes chromatin marks and mediates downstream cellular effects (PubMed:29061846, PubMed:36927955). Promotes canonical WNT signaling, and is involved in the down-regulation of cell proliferation (PubMed:36927955)