SPRY1

Chr 4q28.1

sprouty RTK signaling antagonist 1

Aliases:: hSPRY1
MANE:: ENST00000651917.1

OMIM: 602465 ↗NCBI: 10252 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SPRY1 · O43609

v62025-08-01

Predicted Aligned Error matrix for SPRY1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

62.1/ 100

Low

319 residues

Confidence breakdown

Very high(≥ 90)14%
Confident(70–90)27%
Low(50–70)13%
Very low(< 50)46%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Rare syndromic craniosynostosis or isolated multisuture synostosis
BIALLELIC, autosomal or pseudoautosomal
CAKUT
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Unexplained kidney failure in young people
Unexplained young onset end-stage renal disease - additional genes
Unknown

Disease associations (Open Targets)

neurodegenerative disease
0.37
Barrett esophagus
0.36
chronic hepatitis
0.33
esophageal adenocarcinoma
0.31
ovarian dysfunction
0.31
hypertensive disorder
0.28
hereditary disease
0.27
peptic ulcer disease
0.26
cervical carcinoma
0.25
androgenetic alopecia
0.25

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein sprouty homolog 1

Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity)