SPRY4

Chr 5q31.3

sprouty RTK signaling antagonist 4

MANE:: ENST00000434127.3

OMIM: 607984 ↗NCBI: 81848 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

SPRY4 · Q9C004

v62025-08-01

Predicted Aligned Error matrix for SPRY4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

60.9/ 100

Low

299 residues

Confidence breakdown

Very high(≥ 90)7%
Confident(70–90)32%
Low(50–70)17%
Very low(< 50)44%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Hypogonadotropic hypogonadism
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Hypogonadotropic hypogonadism (GMS)
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
Unknown
Rare syndromic craniosynostosis or isolated multisuture synostosis
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Kallmann syndrome
0.75
neurodegenerative disease
0.53
hypogonadotropic hypogonadism
0.44
Abnormality of the skeletal system
0.42
testicular cancer
0.40
insomnia
0.40
type 2 diabetes mellitus
0.38
osteoarthritis, hand
0.34
osteoarthritis, knee
0.31
cancer
0.30

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein sprouty homolog 4

Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898)