SRP19

Chr 5q22.2

signal recognition particle 19

MANE:: ENST00000505459.6

OMIM: 182175 ↗NCBI: 6728 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

SRP19 · P09132

v62025-08-01

Predicted Aligned Error matrix for SRP19 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.8/ 100

Confident

144 residues

Confidence breakdown

Very high(≥ 90)73%
Confident(70–90)6%
Low(50–70)7%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Cytopenia - NOT Fanconi anaemia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

familial adenomatous polyposis 1
0.42
severe congenital neutropenia
0.38
autosomal dominant severe congenital neutropenia
0.37
Shwachman-Diamond syndrome 1
0.33
neurodegenerative disease
0.28
arthropathy
0.10
aortic valve stenosis
0.04
stroke disorder
0.04
alcohol drinking
0.04
cancer
0.02

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Signal recognition particle 19 kDa protein

Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity)