SRPRA

Chr 11q24.2

SRP receptor subunit alpha

Aliases:: SRP-alpha, Sralpha, SR-alpha
MANE:: ENST00000332118.11

OMIM: 182180 ↗NCBI: 6734 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SRPRA · P08240

v62025-08-01

Predicted Aligned Error matrix for SRPRA — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.8/ 100

Confident

638 residues

Confidence breakdown

Very high(≥ 90)33%
Confident(70–90)33%
Low(50–70)11%
Very low(< 50)23%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Cytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

severe congenital neutropenia
0.38
Shwachman-Diamond syndrome 1
0.33
autism spectrum disorder
0.09
coronary artery disorder
0.05
lymphatic system disorder
0.04
alcohol drinking
0.04
myocardial infarction
0.03
coronary atherosclerosis
0.02
sialadenitis
0.02
spermatocele
0.02

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Signal recognition particle receptor subunit alpha

Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957)