AlphaFold predicted structure
SSR3 · Q9UNL2
Mean pLDDT
84.4/ 100
Confident
185 residues
Confidence breakdown
- Very high(≥ 90)47%
- Confident(70–90)36%
- Low(50–70)16%
- Very low(< 50)2%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
SSR3
Chr 3q25.31signal sequence receptor subunit 3
- Aliases:
- TRAPG
- MANE:
- ENST00000265044.7
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Congenital disorders of glycosylation
BIALLELIC, autosomal or pseudoautosomalLikely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
neurodegenerative disease
0.37congenital disorder of glycosylation
0.32testicular germ cell tumor
0.31type 1 diabetes mellitus
0.29alcohol drinking
0.29obesity disorder
0.26sensorineural hearing loss disorder
0.25placenta praevia
0.07liver disorder
0.07Age-related nuclear cataract
0.07
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Translocon-associated protein subunit gamma
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins