AlphaFold predicted structure
ST14 · Q9Y5Y6
Mean pLDDT
80.9/ 100
Confident
855 residues
Confidence breakdown
- Very high(≥ 90)34%
- Confident(70–90)47%
- Low(50–70)12%
- Very low(< 50)7%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
ST14
Chr 11q24.3ST14 transmembrane serine protease matriptase
- Aliases:
- SNC19, HAI, MT-SP1, TMPRSS14, CAP3
- MANE:
- ENST00000278742.6
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Autosomal recessive congenital ichthyosis
BIALLELIC, autosomal or pseudoautosomalDDG2P
BIALLELIC, autosomal or pseudoautosomalEctodermal dysplasia
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalIchthyosis and erythrokeratoderma
BIALLELIC, autosomal or pseudoautosomalFamilial cicatricial alopecia
BIALLELIC, autosomal or pseudoautosomalPalmoplantar keratodermas
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
Ichthyosis-hypotrichosis syndrome
0.73autosomal recessive congenital ichthyosis 11
0.71Abnormality of the skeletal system
0.35ovarian neoplasm
0.29benign neoplasm of pituitary gland
0.29ichthyosis
0.27hereditary disease
0.19breast cancer
0.12breast carcinoma
0.12myopia
0.11
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Suppressor of tumorigenicity 14 protein
Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (PubMed:10373424). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (PubMed:18843291). Proteolytically cleaves and therefore activates TMPRSS13 (PubMed:28710277)