STAT6

Chr 12q13.3

signal transducer and activator of transcription 6

Aliases:: D12S1644, IL-4-STAT
MANE:: ENST00000300134.8

OMIM: 601512 ↗NCBI: 6778 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

STAT6 · P42226

v62025-08-01

Predicted Aligned Error matrix for STAT6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.5/ 100

Confident

847 residues

Confidence breakdown

Very high(≥ 90)53%
Confident(70–90)18%
Low(50–70)5%
Very low(< 50)24%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
COVID-19 research
Unknown

Disease associations (Open Targets)

hyper-IgE syndrome 6, autosomal dominant, with recurrent infections
0.73
asthma
0.47
diffuse large B-cell lymphoma
0.44
allergic disease
0.43
respiratory system disorder
0.41
allergic rhinitis
0.40
Wheezing
0.40
adult onset asthma
0.39
lymphoma
0.39
solitary fibrous tumor
0.38

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Signal transducer and activator of transcription 6

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling