AlphaFold predicted structure
STEAP3 · Q658P3
Mean pLDDT
89.2/ 100
Confident
488 residues
Confidence breakdown
- Very high(≥ 90)82%
- Confident(70–90)8%
- Low(50–70)2%
- Very low(< 50)9%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
STEAP3
Chr 2q14.2STEAP3 metalloreductase
- Aliases:
- TSAP6, dudlin-2, STMP3
- MANE:
- ENST00000393110.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Iron metabolism disorders - NOT common HFE mutations
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownRare anaemia
Disease associations (Open Targets)
severe congenital hypochromic anemia with ringed sideroblasts
0.50ovarian neoplasm
0.29autoimmune thyroid disease
0.29trauma complication
0.28ocular hypotension
0.28bone remodeling disease
0.22hypochromic anemia
0.19primary ciliary dyskinesia
0.15Abnormal nasolacrimal system morphology
0.13central nervous system cancer
0.11
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Metalloreductase STEAP3
Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:26205815). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (PubMed:15319436, PubMed:16651434)