serine/threonine kinase 11
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Diagnostic Grade (Green)
Adult solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownAdult solid tumours for rare disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownChildhood solid tumours
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownChildhood solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownColorectal cancer pertinent cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedFamilial breast cancer
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedGI tract tumours
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedInherited pancreatic cancer
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown+6 more panels — install the extension to see the full list inline on any page.
Peutz-Jeghers syndrome
familial pancreatic carcinoma
lung adenocarcinoma
melanoma, cutaneous malignant, susceptibility to, 1
testicular germ cell tumor
Inherited cancer-predisposing syndrome
hereditary neoplastic syndrome
non-small cell lung carcinoma
familial ovarian cancer
cervical squamous cell carcinoma
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Serine/threonine-protein kinase STK11
Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response (PubMed:12805220, PubMed:14517248, PubMed:14976552, PubMed:15016379, PubMed:15733851). Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK (PubMed:12805220, PubMed:14517248, PubMed:14976552, PubMed:15016379, PubMed:15733851). Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53 (PubMed:11430832, PubMed:15987703). Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage (PubMed:14976552). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton (PubMed:15016379). Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification (PubMed:14976552). Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation (PubMed:11430832, PubMed:17108107, PubMed:21317932). Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1 (PubMed:11430832, PubMed:17108107, PubMed:21317932). Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways (PubMed:11430832, PubMed:17108107, PubMed:21317932). Regulates UV radiation-induced DNA damage response mediated by CDKN1A (PubMed:25329316). In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316)
Curated MONDO disease pages that list STK11 among their top associated genes.
STK11 · Q15831
Mean pLDDT
78.8/ 100
Confident
433 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
