STK36

Chr 2q35

serine/threonine kinase 36

Aliases:: KIAA1278, FU
MANE:: ENST00000295709.8

OMIM: 607652 ↗NCBI: 27148 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

STK36 · Q9NRP7

v62025-08-01

Predicted Aligned Error matrix for STK36 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.9/ 100

Confident

1,315 residues

Confidence breakdown

Very high(≥ 90)47%
Confident(70–90)36%
Low(50–70)6%
Very low(< 50)12%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

ciliary dyskinesia, primary, 46
0.56
primary ciliary dyskinesia
0.39
neurodegenerative disease
0.31
spermatogenic failure 18
0.27
posterior cortical atrophy
0.08
focal segmental glomerulosclerosis
0.07
familial idiopathic steroid-resistant nephrotic syndrome
0.07
Joubert syndrome
0.05
proteinuria, chronic benign
0.05
Abnormality of the skeletal system
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Serine/threonine-protein kinase 36

Serine/threonine protein kinase which plays an important role in the smoothened pathway by regulating the activity of GLI transcription factors (PubMed:10806483, PubMed:28543983, PubMed:31279575, PubMed:38096226). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483, PubMed:31279575, PubMed:38096226). Acts by mediating phosphorylation of GLI proteins, promoting their dissociation from SUFU (PubMed:28543983, PubMed:31279575, PubMed:38096226). Also catalyzes phosphorylation of ULK4 adapter (PubMed:38096226). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (PubMed:28543983). Essential for construction of the central pair apparatus of motile cilia (PubMed:28543983)