STRADA

Chr 17q23.3

STE20 related adaptor alpha

Aliases:: STLK5, NY-BR-96, LYK5, Stlk, STRAD
MANE:: ENST00000336174.12

OMIM: 608626 ↗NCBI: 92335 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

STRADA · Q7RTN6

v62025-08-01

Predicted Aligned Error matrix for STRADA — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.0/ 100

Confident

431 residues

Confidence breakdown

Very high(≥ 90)64%
Confident(70–90)10%
Low(50–70)4%
Very low(< 50)22%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Hydrocephalus
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Nephrocalcinosis or nephrolithiasis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

polyhydramnios, megalencephaly, and symptomatic epilepsy
0.75
Rolandic epilepsy
0.46
self-limited epilepsy with centrotemporal spikes
0.45
neurodegenerative disease
0.41
Severe global developmental delay
0.37
Parkinson disease
0.29
Alzheimer disease
0.28
multiple sclerosis
0.27
lysosomal storage disease
0.27
hereditary disease
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

STE20-related kinase adapter protein alpha

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation