STRC

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Monogenic hearing loss

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• hearing loss, autosomal recessive

  0.71

• Rare genetic deafness

  0.67

• deafness-infertility syndrome

  0.59

• nonsyndromic genetic hearing loss

  0.52

• hereditary disease

  0.45

• autosomal dominant nonsyndromic hearing loss

  0.45

• spermatogenic failure 7

  0.44

• Non-syndromic genetic deafness

  0.39

• deafness

  0.36

• Hearing impairment

  0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)