SUCO

Chr 1q24.3

SUN domain containing ossification factor

Aliases:: CH1, SLP1, OPT
MANE:: ENST00000263688.4

OMIM: 619434 ↗NCBI: 51430 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SUCO · Q9UBS9

v62025-08-01

Predicted Aligned Error matrix for SUCO — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

52.4/ 100

Low

1,254 residues

Confidence breakdown

Very high(≥ 90)17%
Confident(70–90)11%
Low(50–70)6%
Very low(< 50)66%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Osteogenesis imperfecta
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

osteogenesis imperfecta
0.25
skeletal dysplasia
0.23
Osteopenia
0.23
breast cancer
0.11
venous thromboembolism
0.11
hepatocellular carcinoma
0.08
Hypocalcemic vitamin D-dependent rickets
0.06
head and neck squamous cell carcinoma
0.06
Hypocalcemic vitamin D-resistant rickets
0.06
hereditary hypophosphatemic rickets with hypercalciuria
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

SUN domain-containing ossification factor

Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity)