SULT2B1

Chr 19q13.33

sulfotransferase family 2B member 1

Aliases:: HSST2
MANE:: ENST00000201586.7

OMIM: 604125 ↗NCBI: 6820 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SULT2B1 · O00204

v62025-08-01

Predicted Aligned Error matrix for SULT2B1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.7/ 100

Confident

365 residues

Confidence breakdown

Very high(≥ 90)75%
Confident(70–90)6%
Low(50–70)6%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Autosomal recessive congenital ichthyosis
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Ichthyosis and erythrokeratoderma
BIALLELIC, autosomal or pseudoautosomal
Palmoplantar keratodermas
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

ichthyosis, congenital, autosomal recessive 14
0.69
congenital non-bullous ichthyosiform erythroderma
0.56
Ichthyosis-hypotrichosis syndrome
0.55
self-healing collodion baby
0.46
ichthyosis
0.38
inherited ichthyosis
0.37
lamellar ichthyosis
0.37
congenital reticular ichthyosiform erythroderma
0.37
autosomal recessive congenital ichthyosis
0.35
hereditary disease
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Sulfotransferase 2B1

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:12145317, PubMed:19589875). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:12145317, PubMed:16855051, PubMed:21855633, PubMed:9799594). Preferentially sulfonates cholesterol, while it also has significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648)