AlphaFold predicted structure
SUOX · P51687
Mean pLDDT
84.7/ 100
Confident
545 residues
Confidence breakdown
- Very high(≥ 90)68%
- Confident(70–90)15%
- Low(50–70)2%
- Very low(< 50)15%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
SUOX
Chr 12q13.2sulfite oxidase
- MANE:
- ENST00000266971.8
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Childhood onset dystonia, chorea or related movement disorder
BIALLELIC, autosomal or pseudoautosomalDDG2P
BIALLELIC, autosomal or pseudoautosomalEarly onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalLikely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalUndiagnosed metabolic disorders
BIALLELIC, autosomal or pseudoautosomalAdult onset dystonia, chorea or related movement disorder
BIALLELIC, autosomal or pseudoautosomalAdult onset neurodegenerative disorder
Unknown
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Disease associations (Open Targets)
isolated sulfite oxidase deficiency
0.83encephalopathy due to sulfite oxidase deficiency
0.65asthma
0.56Sulfocysteinuria
0.52rheumatoid arthritis
0.52type 1 diabetes mellitus
0.52hereditary disease
0.50childhood onset asthma
0.49hypothyroidism
0.47allergic disease
0.47
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Sulfite oxidase, mitochondrial
Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids (By similarity). Can run in reverse direction and reduce nitrite to nitric oxide under physiologically relevant conditions, such as hypoxia (PubMed:41337830)