SYCE1

Chr 10q26.3

synaptonemal complex central element protein 1

Aliases:: bA108K14.6, CT76
MANE:: ENST00000343131.7

OMIM: 611486 ↗NCBI: 93426 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SYCE1 · Q8N0S2

v62025-08-01

Predicted Aligned Error matrix for SYCE1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.5/ 100

Confident

351 residues

Confidence breakdown

Very high(≥ 90)56%
Confident(70–90)7%
Low(50–70)11%
Very low(< 50)26%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary ovarian insufficiency
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

premature ovarian failure 12
0.55
spermatogenic failure 15
0.51
male infertility with azoospermia or oligozoospermia due to single gene mutation
0.39
Primary amenorrhea
0.32
primary ovarian failure
0.28
urolithiasis
0.22
alcohol drinking
0.22
spermatogenic failure
0.08
partial chromosome Y deletion
0.08
non-syndromic male infertility due to sperm motility disorder
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Synaptonemal complex central element protein 1

Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination