AlphaFold predicted structure
SYCP2L · Q5T4T6
Mean pLDDT
65.9/ 100
Low
812 residues
Confidence breakdown
- Very high(≥ 90)35%
- Confident(70–90)20%
- Low(50–70)6%
- Very low(< 50)39%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
SYCP2L
Chr 6p24.2synaptonemal complex protein 2 like
- Aliases:
- dJ62D2.1, NO145
- MANE:
- ENST00000283141.11
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Primary ovarian insufficiency
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
premature ovarian failure 24
0.42menopause
0.34ovulation
0.32neurodegenerative disease
0.28prostate carcinoma
0.25premature menopause
0.19Premature ovarian insufficiency
0.19hyperparathyroidism
0.16parathyroid gland disorder
0.16endocrine system disorder
0.14
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Synaptonemal complex protein 2-like
Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes