TAC3

Chr 12q13.3

tachykinin precursor 3

Aliases:: ZNEUROK1, NKB, NK3, LncZBTB39-1:2, LncZBTB39
MANE:: ENST00000458521.7

OMIM: 162330 ↗NCBI: 6866 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

TAC3 · Q9UHF0

v62025-08-01

Predicted Aligned Error matrix for TAC3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

64.9/ 100

Low

121 residues

Confidence breakdown

Very high(≥ 90)9%
Confident(70–90)26%
Low(50–70)47%
Very low(< 50)17%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Hypogonadotropic hypogonadism
BIALLELIC, autosomal or pseudoautosomal
Hypogonadotropic hypogonadism (GMS)
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hypogonadotropic hypogonadism
0.62
hypogonadotropic hypogonadism 10 with or without anosmia
0.60
isolated congenital hypogonadotropic hypogonadism
0.60
Kallmann syndrome
0.46
Delayed puberty
0.33
infertility disorder
0.33
transient ischemic attack
0.21
polycystic ovary syndrome
0.09
46,XX gonadal dysgenesis
0.07
male infertility with azoospermia or oligozoospermia due to single gene mutation
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tachykinin-3

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles