TACR3

Chr 4q24

tachykinin receptor 3

Aliases:: NK3R, NKR, TAC3R
MANE:: ENST00000304883.3

OMIM: 162332 ↗NCBI: 6870 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

TACR3 · P29371

v62025-08-01

Predicted Aligned Error matrix for TACR3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

72.8/ 100

Confident

465 residues

Confidence breakdown

Very high(≥ 90)42%
Confident(70–90)22%
Low(50–70)3%
Very low(< 50)33%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Hypogonadotropic hypogonadism
BIALLELIC, autosomal or pseudoautosomal
Hypogonadotropic hypogonadism (GMS)
BIALLELIC, autosomal or pseudoautosomal
Differences in sex development
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hypogonadotropic hypogonadism 11 with or without anosmia
0.69
hypogonadotropic hypogonadism
0.66
isolated congenital hypogonadotropic hypogonadism
0.64
menopause
0.57
Hot flashes
0.55
Abnormality of the skeletal system
0.50
Kallmann syndrome
0.47
testicular disorder
0.38
isolated thyroid-stimulating hormone deficiency
0.37
breast neoplasm
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Neuromedin-K receptor

Receptor for the tachykinin neuromedin-K (neurokinin B), also able to bind and respond to tachynins substance K/neurokinin A and substance P (PubMed:1312036, PubMed:37391393). The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K and substance P (PubMed:1312036). Neuromedin-K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:37391393). Neuromedin-K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity)