TAF13

Chr 1p13.3

TATA-box binding protein associated factor 13

Aliases:: TAFII18
MANE:: ENST00000338366.6

OMIM: 600774 ↗NCBI: 6884 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TAF13 · Q15543

v62025-08-01

Predicted Aligned Error matrix for TAF13 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.5/ 100

Confident

124 residues

Confidence breakdown

Very high(≥ 90)65%
Confident(70–90)10%
Low(50–70)7%
Very low(< 50)18%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

intellectual disability, autosomal recessive 60
0.65
HIV infectious disease
0.58
neurodegenerative disease
0.55
autosomal recessive primary microcephaly
0.40
microcephaly with intellectual disability
0.37
ovarian neoplasm
0.24
lysosomal storage disease
0.17
hereditary disease
0.12
open-angle glaucoma
0.03
Abnormal sperm morphology
0.02

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transcription initiation factor TFIID subunit 13

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473, PubMed:9695952). TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes (PubMed:33795473)