TAF1C

Chr 16q24.1

TATA-box binding protein associated factor, RNA polymerase I subunit C

Aliases:: TAFI110, TAFI95, SL1, MGC:39976
MANE:: ENST00000566732.6

OMIM: 604905 ↗NCBI: 9013 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TAF1C · Q15572

v62025-08-01

Predicted Aligned Error matrix for TAF1C — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

64.5/ 100

Low

869 residues

Confidence breakdown

Very high(≥ 90)18%
Confident(70–90)36%
Low(50–70)13%
Very low(< 50)34%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.46
Global developmental delay
0.19
Intellectual disability
0.18
Seizure
0.18
Strabismus
0.18
Spasticity
0.18
primary ciliary dyskinesia
0.12
Hematemesis
0.05
ovarian dysfunction
0.05
type 2 diabetes mellitus
0.01

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

TATA box-binding protein-associated factor RNA polymerase I subunit C

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3