TAF6

Chr 7q22.1

TATA-box binding protein associated factor 6

Aliases:: TAFII70, TAFII80, MGC:8964, TAFII85
MANE:: ENST00000453269.7

OMIM: 602955 ↗NCBI: 6878 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TAF6 · P49848

v62025-08-01

Predicted Aligned Error matrix for TAF6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

63.4/ 100

Low

677 residues

Confidence breakdown

Very high(≥ 90)9%
Confident(70–90)41%
Low(50–70)13%
Very low(< 50)37%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Alazami-Yuan syndrome
0.68
HIV infectious disease
0.58
hereditary disease
0.47
neurodegenerative disease
0.42
Intellectual disability
0.41
Cornelia de Lange syndrome
0.33
syndromic intellectual disability
0.33
Global developmental delay
0.26
Abnormal facial shape
0.26
hereditary spastic paraplegia
0.15

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transcription initiation factor TFIID subunit 6

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473)