TANC2

Chr 17q23.2-q23.3

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

Aliases:: DKFZP564D166, FLJ10215, FLJ11824, KIAA1148, KIAA1636
MANE:: ENST00000689528.1

OMIM: 615047 ↗NCBI: 26115 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TANC2 · Q9HCD6

v62025-08-01

Predicted Aligned Error matrix for TANC2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

59.5/ 100

Low

1,990 residues

Confidence breakdown

Very high(≥ 90)28%
Confident(70–90)20%
Low(50–70)3%
Very low(< 50)49%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Early onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

intellectual developmental disorder with autistic features and language delay, with or without seizures
0.79
hereditary disease
0.51
Intellectual disability
0.46
neurodevelopmental disorder
0.39
complex neurodevelopmental disorder
0.37
autism spectrum disorder
0.37
insomnia
0.35
intelligence
0.34
epilepsy
0.33
ovarian neoplasm
0.30

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein TANC2

Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines