TAPBP

Chr 6p21.32

TAP binding protein

Aliases:: TAPA, TPN, TPSN, NGS17
MANE:: ENST00000434618.7

OMIM: 601962 ↗NCBI: 6892 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TAPBP · O15533

v62025-08-01

Predicted Aligned Error matrix for TAPBP — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

87.1/ 100

Confident

448 residues

Confidence breakdown

Very high(≥ 90)63%
Confident(70–90)25%
Low(50–70)7%
Very low(< 50)5%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

MHC class I deficiency
0.57
Immunodeficiency by defective expression of HLA class 1
0.51
MHC class I deficiency 3
0.38
neoplasm
0.10
malaria
0.08
neuroblastoma
0.07
cancer
0.06
glioblastoma
0.05
Wiskott-Aldrich syndrome
0.05
melanoma
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tapasin

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading)