TBCB

Chr 19q13.12

tubulin folding cofactor B

Aliases:: CG22, CKAPI
MANE:: ENST00000221855.8

OMIM: 601303 ↗NCBI: 1155 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

TBCB · Q99426

v62025-08-01

Predicted Aligned Error matrix for TBCB — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

92.4/ 100

Very high

244 residues

Confidence breakdown

Very high(≥ 90)84%
Confident(70–90)12%
Low(50–70)3%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Childhood onset hereditary spastic paraplegia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.55
atrial fibrillation
0.20
neurodevelopmental disorder
0.18
lysosomal storage disease
0.09
acute myeloid leukemia
0.07
membranous glomerulonephritis
0.03
neoplasm
0.02
ovarian carcinoma
0.02
Sepsis
0.02
breast cancer
0.01

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tubulin-folding cofactor B

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity)