TBXA2R

Chr 19p13.3

thromboxane A2 receptor

MANE:: ENST00000375190.10

OMIM: 188070 ↗NCBI: 6915 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TBXA2R · P21731

v62025-08-01

Predicted Aligned Error matrix for TBXA2R — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.3/ 100

Confident

343 residues

Confidence breakdown

Very high(≥ 90)65%
Confident(70–90)20%
Low(50–70)9%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Inherited bleeding disorders
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

Disease associations (Open Targets)

bleeding diathesis due to thromboxane synthesis deficiency
0.60
neurodegenerative disease
0.51
Airway obstruction
0.37
Recurrent thrombophlebitis
0.37
Abnormal platelet aggregation
0.30
thrombotic disease
0.26
allergic asthma
0.26
autoimmune disorder of central nervous system
0.20
hereditary disease
0.19
atopic asthma
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Thromboxane A2 receptor

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C