TCEAL1

Chr Xq22.2

transcription elongation factor A like 1

Aliases:: p21, pp21, SIIR, P21, WEX9
MANE:: ENST00000372625.8

OMIM: 300237 ↗NCBI: 9338 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TCEAL1 · Q15170

v62025-08-01

Predicted Aligned Error matrix for TCEAL1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

67.1/ 100

Low

159 residues

Confidence breakdown

Very high(≥ 90)17%
Confident(70–90)20%
Low(50–70)50%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Intellectual disability
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

Disease associations (Open Targets)

neurodevelopmental disorder with gait disturbance, dysmorphic facies, and behavioral abnormalities, X-linked
0.68
hereditary disease
0.40
neurodegenerative disease
0.30
neurodevelopmental disorder
0.19
melanoma
0.07
neuroblastoma
0.04
neoplasm
0.03
prostate carcinoma
0.03
prostate cancer
0.03
Familial prostate cancer
0.03

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transcription elongation factor A protein-like 1

May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly