TCF3

Chr 19p13.3

transcription factor 3

Aliases:: E2A, ITF1, MGC129647, MGC129648, bHLHb21
MANE:: ENST00000262965.12

OMIM: 147141 ↗NCBI: 6929 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TCF3 · P15923

v62025-08-01

Predicted Aligned Error matrix for TCF3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

51.1/ 100

Low

654 residues

Confidence breakdown

Very high(≥ 90)11%
Confident(70–90)5%
Low(50–70)14%
Very low(< 50)70%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Haematological malignancies cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

agammaglobulinemia 8, autosomal dominant
0.69
agammaglobulinemia 8b, autosomal recessive
0.64
neurodegenerative disease
0.50
autosomal agammaglobulinemia
0.47
B-cell acute lymphoblastic leukemia
0.42
hereditary disease
0.42
acute lymphoblastic leukemia
0.40
T-cell acute lymphoblastic leukemia
0.37
hemangioblastoma
0.37
lung adenocarcinoma in situ
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transcription factor 7-like 1

Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance