AlphaFold predicted structure
TCF7L2 · Q9NQB0
Mean pLDDT
53.0/ 100
Low
619 residues
Confidence breakdown
- Very high(≥ 90)9%
- Confident(70–90)8%
- Low(50–70)17%
- Very low(< 50)65%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TCF7L2
Chr 10q25.2-q25.3transcription factor 7 like 2
- Aliases:
- TCF-4
- MANE:
- ENST00000355995.9
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
type 2 diabetes mellitus
0.67colorectal adenocarcinoma
0.61prostate carcinoma
0.58diabetes mellitus
0.57breast carcinoma
0.54myopia
0.54type 1 diabetes mellitus
0.53colon adenocarcinoma
0.52coronary artery disorder
0.51gestational diabetes
0.51
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Transcription factor 7-like 2
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine
Diseases associated with TCF7L2
Curated MONDO disease pages that list TCF7L2 among their top associated genes.