tudor domain containing 7
Annotations refreshed 9 hours ago.
Diagnostic Grade (Green)
Bilateral congenital or childhood onset cataracts
BIALLELIC, autosomal or pseudoautosomalDDG2P
BIALLELIC, autosomal or pseudoautosomalStructural eye disease
BIALLELIC, autosomal or pseudoautosomalearly-onset non-syndromic cataract
Developmental cataract
gastric cancer
pericarditis
hereditary disease
Posterior polar cataract
Total congenital cataract
cataract
early-onset zonular cataract
Partial congenital cataract
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Tudor domain-containing protein 7
Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis
Curated MONDO disease pages that list TDRD7 among their top associated genes.
TDRD7 · Q8NHU6
Mean pLDDT
73.1/ 100
Confident
1,098 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
