TECTA

Chr 11q23.3

tectorin alpha

MANE:: ENST00000392793.6

OMIM: 602574 ↗NCBI: 7007 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

TECTA · O75443

v62025-08-01

Predicted Aligned Error matrix for TECTA — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.4/ 100

Confident

2,155 residues

Confidence breakdown

Very high(≥ 90)18%
Confident(70–90)60%
Low(50–70)13%
Very low(< 50)9%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Monogenic hearing loss
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

autosomal dominant nonsyndromic hearing loss
0.73
hearing loss, autosomal recessive
0.73
nonsyndromic genetic hearing loss
0.66
hearing loss disorder
0.63
deafness
0.63
Rare genetic deafness
0.53
Sensorineural hearing impairment
0.50
Non-syndromic genetic deafness
0.48
hereditary disease
0.45
Vertigo
0.42

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Alpha-tectorin

One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals

Curated MONDO disease pages that list TECTA among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with TECTA