TENM3

Chr 4q34.3-q35.1

teneurin transmembrane protein 3

Aliases:: Ten-M3, KIAA1455, TEN3
MANE:: ENST00000511685.6

OMIM: 610083 ↗NCBI: 55714 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

TENM3 · Q9P273

v62025-08-01

Predicted Aligned Error matrix for TENM3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.4/ 100

Confident

2,699 residues

Confidence breakdown

Very high(≥ 90)37%
Confident(70–90)42%
Low(50–70)6%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Anophthalmia or microphthalmia
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Ocular coloboma
BIALLELIC, autosomal or pseudoautosomal
Structural eye disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

microphthalmia, isolated, with coloboma 9
0.75
microphthalmia, isolated, with coloboma
0.67
neurotic disorder
0.42
ovarian neoplasm
0.39
brain aneurysm
0.32
placenta praevia
0.32
Abnormality of limbs
0.32
myasthenia gravis
0.31
liver disorder
0.31
Proptosis
0.31

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Teneurin-3

Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes

Curated MONDO disease pages that list TENM3 among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with TENM3